Drug interactions
Gymnema + Insulin glargine-lixisenatide
Severity: Moderate
Gymnema and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gymnema sylvestre has reported glucose-lowering activity and may add to the effect of insulin and lixisenatide. This could increase the risk of hypoglycemia in patients who take it regularly.
What this interaction means in plain words
Gymnema and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood glucose lowering, possibly through enhanced insulin secretion or reduced intestinal glucose absorption.
What to do
Monitor blood glucose more often if the patient starts or stops gymnema, and reduce the insulin dose if hypoglycemia occurs. Discuss use of herbal products with the diabetes care team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Gymnema with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Gymnema and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gymnema sylvestre has reported glucose-lowering activity and may add to the effect of insulin and lixisenatide. This could increase the risk of hypoglycemia in patients who take it regularly.
How serious is the interaction between Gymnema and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often if the patient starts or stops gymnema, and reduce the insulin dose if hypoglycemia occurs. Discuss use of herbal products with the diabetes care team.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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