Drug interactions
Haemophilus influenzae type b vaccine + Ifosfamide
Severity: Moderate
Haemophilus influenzae type b vaccine and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Myelosuppressive chemotherapy with ifosfamide may blunt antibody responses to Hib conjugate vaccine. Vaccine protection could be suboptimal.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Vaccinate at least 2 weeks before chemotherapy if possible. Revaccinate about 3 months after chemotherapy once immune function recovers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Ifosfamide?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Myelosuppressive chemotherapy with ifosfamide may blunt antibody responses to Hib conjugate vaccine. Vaccine protection could be suboptimal.
How serious is the interaction between Haemophilus influenzae type b vaccine and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy if possible. Revaccinate about 3 months after chemotherapy once immune function recovers.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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