Drug interactions
Henbane + Imipramine
Severity: Moderate
Henbane and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains tropane alkaloids such as hyoscyamine and scopolamine, which are potent antimuscarinics. With imipramine they can cause additive anticholinergic toxicity, including dry mouth, urinary retention, constipation, confusion and tachycardia.
What this interaction means in plain words
Henbane and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid the combination, especially in older adults. Monitor for anticholinergic toxicity if it cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Henbane with Imipramine?
MediHelp rates the interaction as moderate. Henbane and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains tropane alkaloids such as hyoscyamine and scopolamine, which are potent antimuscarinics. With imipramine they can cause additive anticholinergic toxicity, including dry mouth, urinary retention, constipation, confusion and tachycardia.
How serious is the interaction between Henbane and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, especially in older adults. Monitor for anticholinergic toxicity if it cannot be avoided.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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