Drug interactions
Henbane + Nortriptyline
Severity: Moderate
Henbane and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains tropane alkaloids such as hyoscyamine and scopolamine, which add to the anticholinergic burden of nortriptyline. This can cause tachycardia, urinary retention, hyperthermia, confusion and delirium.
What this interaction means in plain words
Henbane and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid combining henbane with nortriptyline where possible. Monitor for anticholinergic toxicity if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Henbane with Nortriptyline?
MediHelp rates the interaction as moderate. Henbane and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains tropane alkaloids such as hyoscyamine and scopolamine, which add to the anticholinergic burden of nortriptyline. This can cause tachycardia, urinary retention, hyperthermia, confusion and delirium.
How serious is the interaction between Henbane and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining henbane with nortriptyline where possible. Monitor for anticholinergic toxicity if both are used.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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