Drug interactions
Henbane + Oxybutynin
Severity: Moderate
Henbane and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to oxybutynin's effects. The combination may cause marked dry mouth, tachycardia, urinary retention, constipation, confusion and hallucinations.
What this interaction means in plain words
Henbane and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic receptor blockade from plant-derived belladonna alkaloids.
What to do
Avoid concurrent use of henbane preparations with oxybutynin; if anticholinergic toxicity occurs, stop the herbal product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Frequently asked questions
Can I take Henbane with Oxybutynin?
MediHelp rates the interaction as moderate. Henbane and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to oxybutynin's effects. The combination may cause marked dry mouth, tachycardia, urinary retention, constipation, confusion and hallucinations.
How serious is the interaction between Henbane and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of henbane preparations with oxybutynin; if anticholinergic toxicity occurs, stop the herbal product.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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