Drug interactions
Henbane + Tolterodine
Severity: Moderate
Henbane and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with tolterodine, anticholinergic effects are additive and may cause dry mouth, urinary retention, constipation, confusion and tachycardia. Alkaloid content in herbal products varies and is unpredictable.
What this interaction means in plain words
Henbane and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects from belladonna-type alkaloids.
What to do
Avoid combining; if unavoidable, monitor for anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Henbane with Tolterodine?
MediHelp rates the interaction as moderate. Henbane and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with tolterodine, anticholinergic effects are additive and may cause dry mouth, urinary retention, constipation, confusion and tachycardia. Alkaloid content in herbal products varies and is unpredictable.
How serious is the interaction between Henbane and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; if unavoidable, monitor for anticholinergic toxicity.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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