Drug interactions
Heparin + Hydrochlorothiazide-valsartan
Severity: Moderate
Heparin and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone secretion, and together with valsartan this can lead to hyperkalemia. The risk is higher with prolonged heparin use, renal impairment, diabetes or other potassium-raising drugs.
What this interaction means in plain words
Heparin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis, adding to the reduction in aldosterone effect produced by angiotensin receptor blockade; the thiazide partly offsets this.
What to do
Check serum potassium and renal function if heparin is continued beyond a few days, especially in patients with risk factors. Treat hyperkalemia and reassess therapy if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Heparin and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone secretion, and together with valsartan this can lead to hyperkalemia. The risk is higher with prolonged heparin use, renal impairment, diabetes or other potassium-raising drugs.
How serious is the interaction between Heparin and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function if heparin is continued beyond a few days, especially in patients with risk factors. Treat hyperkalemia and reassess therapy if potassium rises.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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