Drug interactions
Heparin + Ibrutinib
Severity: Major
Heparin and Ibrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib inhibits platelet function and is linked to bleeding, including major hemorrhage. Combining it with heparin increases this risk.
What this interaction means in plain words
Heparin and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Heparin belongs to Cardiovascular; Ibrutinib belongs to Oncology.
Why it happens
Ibrutinib inhibits BTK and platelet aggregation pathways, adding to heparin anticoagulation.
What to do
Monitor closely for bleeding and platelet counts, and weigh the need for full-dose anticoagulation. Consider holding ibrutinib around procedures or when bleeding occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Heparin with Ibrutinib?
MediHelp rates the interaction as major. Heparin and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibrutinib inhibits platelet function and is linked to bleeding, including major hemorrhage. Combining it with heparin increases this risk.
How serious is the interaction between Heparin and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and platelet counts, and weigh the need for full-dose anticoagulation. Consider holding ibrutinib around procedures or when bleeding occurs.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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