Drug interactions
Heparin + Meclofenamic acid
Severity: Major
Heparin and Meclofenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin anticoagulation combined with NSAID-induced platelet inhibition and gastric mucosal injury raises the risk of hemorrhage. Gastrointestinal bleeding is of particular concern.
What this interaction means in plain words
Heparin and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Heparin belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect of NSAID antiplatelet action and mucosal damage with heparin-mediated antithrombin potentiation.
What to do
Avoid combining where possible and use a non-NSAID analgesic. If unavoidable, monitor for bleeding, hemoglobin and aPTT or anti-Xa as appropriate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Meclofenamic acid?
MediHelp rates the interaction as major. Heparin and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Heparin anticoagulation combined with NSAID-induced platelet inhibition and gastric mucosal injury raises the risk of hemorrhage. Gastrointestinal bleeding is of particular concern.
How serious is the interaction between Heparin and Meclofenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and use a non-NSAID analgesic. If unavoidable, monitor for bleeding, hemoglobin and aPTT or anti-Xa as appropriate.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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