Drug interactions
Heparin + Sacubitril-valsartan
Severity: Moderate
Heparin and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone synthesis, which may lead to hyperkalemia, and this effect is additive with the potassium-raising action of sacubitril-valsartan. The risk is greatest with prolonged use, renal impairment or diabetes.
What this interaction means in plain words
Heparin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone secretion combined with RAAS blockade reduces renal potassium excretion.
What to do
Check serum potassium at baseline and periodically during prolonged heparin therapy. Treat hyperkalemia if it occurs and reassess the need for continued combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Heparin and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone synthesis, which may lead to hyperkalemia, and this effect is additive with the potassium-raising action of sacubitril-valsartan. The risk is greatest with prolonged use, renal impairment or diabetes.
How serious is the interaction between Heparin and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically during prolonged heparin therapy. Treat hyperkalemia if it occurs and reassess the need for continued combination.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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