Drug interactions
Heparin + Trandolapril
Severity: Moderate
Heparin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress adrenal aldosterone secretion and cause hyperkalemia. With an ACE inhibitor the risk is additive, especially in diabetes, renal impairment or prolonged heparin use.
What this interaction means in plain words
Heparin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Trandolapril belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis added to ACE inhibitor reduction of aldosterone release.
What to do
Monitor serum potassium, particularly with heparin therapy beyond a few days or reduced renal function. Treat hyperkalemia if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Trandolapril?
MediHelp rates the interaction as moderate. Heparin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress adrenal aldosterone secretion and cause hyperkalemia. With an ACE inhibitor the risk is additive, especially in diabetes, renal impairment or prolonged heparin use.
How serious is the interaction between Heparin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with heparin therapy beyond a few days or reduced renal function. Treat hyperkalemia if it develops.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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