Drug interactions
Heparin + Valsartan
Severity: Moderate
Heparin and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin suppresses adrenal aldosterone secretion, and valsartan blocks angiotensin II effects on aldosterone, so together they can raise serum potassium. Risk is greater with renal impairment, diabetes, or other potassium-raising drugs.
What this interaction means in plain words
Heparin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive reduction of aldosterone-mediated potassium excretion (heparin-induced aldosterone suppression plus angiotensin receptor blockade).
What to do
Monitor serum potassium and renal function, particularly when heparin is given for more than a few days or in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Valsartan?
MediHelp rates the interaction as moderate. Heparin and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin suppresses adrenal aldosterone secretion, and valsartan blocks angiotensin II effects on aldosterone, so together they can raise serum potassium. Risk is greater with renal impairment, diabetes, or other potassium-raising drugs.
How serious is the interaction between Heparin and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly when heparin is given for more than a few days or in high-risk patients.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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