Drug interactions
Hepatitis a / b vaccine + Prednisolone
Severity: Moderate
Hepatitis a / b vaccine and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a non-live vaccine and is safe to give, but immunosuppressive prednisolone doses may reduce seroconversion and antibody levels. Protection against hepatitis A and B may be incomplete.
What this interaction means in plain words
Hepatitis a / b vaccine and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid suppression of B- and T-cell function reduces vaccine-induced antibody production.
What to do
Complete the schedule and check anti-HBs titres after vaccination in patients on prolonged steroids. Revaccinate non-responders as per guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Prednisolone?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a non-live vaccine and is safe to give, but immunosuppressive prednisolone doses may reduce seroconversion and antibody levels. Protection against hepatitis A and B may be incomplete.
How serious is the interaction between Hepatitis a / b vaccine and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the schedule and check anti-HBs titres after vaccination in patients on prolonged steroids. Revaccinate non-responders as per guidance.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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