Drug interactions
Hepatitis a / b vaccine + Tocilizumab
Severity: Moderate
Hepatitis a / b vaccine and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This inactivated combination vaccine may produce a weaker antibody response during tocilizumab therapy. It is not contraindicated.
What this interaction means in plain words
Hepatitis a / b vaccine and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: IL-6 receptor blockade may reduce vaccine-induced antibody production.
What to do
Vaccinate before starting tocilizumab where possible. Check anti-HBs and anti-HAV titres after the series in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Tocilizumab?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This inactivated combination vaccine may produce a weaker antibody response during tocilizumab therapy. It is not contraindicated.
How serious is the interaction between Hepatitis a / b vaccine and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting tocilizumab where possible. Check anti-HBs and anti-HAV titres after the series in at-risk patients.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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