Drug interactions
Hepatitis a / typhoid vaccine + Prednisolone
Severity: Minor
Hepatitis a / typhoid vaccine and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination is a non-live vaccine (inactivated hepatitis A with Vi polysaccharide typhoid), so it can be given safely, but immunosuppressive prednisolone doses may reduce the antibody response. Protection may be lower.
What this interaction means in plain words
Hepatitis a / typhoid vaccine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid suppression of lymphocyte function reduces vaccine-induced antibody production.
What to do
Vaccinate at least 2 weeks before travel where possible. Maintain food and water precautions and consider booster doses if given during high-dose steroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Hepatitis a / typhoid vaccine with Prednisolone?
MediHelp rates the interaction as minor. Hepatitis a / typhoid vaccine and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This combination is a non-live vaccine (inactivated hepatitis A with Vi polysaccharide typhoid), so it can be given safely, but immunosuppressive prednisolone doses may reduce the antibody response. Protection may be lower.
How serious is the interaction between Hepatitis a / typhoid vaccine and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before travel where possible. Maintain food and water precautions and consider booster doses if given during high-dose steroids.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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