Drug interactions
Hepatitis a / typhoid vaccine + Tocilizumab
Severity: Minor
Hepatitis a / typhoid vaccine and Tocilizumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combined vaccine is inactivated and can be used with tocilizumab, but immune response may be reduced. Protection for travel may therefore be less reliable.
What this interaction means in plain words
Hepatitis a / typhoid vaccine and Tocilizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: IL-6 receptor blockade may modestly blunt antibody response.
What to do
Vaccinate at least 2 weeks before travel, ideally before tocilizumab. Maintain food and water precautions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Hepatitis a / typhoid vaccine with Tocilizumab?
MediHelp rates the interaction as minor. Hepatitis a / typhoid vaccine and Tocilizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This combined vaccine is inactivated and can be used with tocilizumab, but immune response may be reduced. Protection for travel may therefore be less reliable.
How serious is the interaction between Hepatitis a / typhoid vaccine and Tocilizumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before travel, ideally before tocilizumab. Maintain food and water precautions.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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