Drug interactions
Hepatitis A vaccine inactivated + Ibrutinib
Severity: Moderate
Hepatitis A vaccine inactivated and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs B-cell receptor signalling and can blunt antibody responses to vaccines. An inactivated hepatitis A vaccine given during treatment may therefore produce a weaker or shorter-lived protective response.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Ibrutinib belongs to Oncology.
Why it happens
Ibrutinib inhibits Bruton tyrosine kinase, reducing B-cell activation and antibody production after vaccination.
What to do
Where possible, vaccinate before starting ibrutinib; if given during therapy, consider checking antibody titres in at-risk patients and revaccinating after treatment ends or when immune function recovers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Ibrutinib?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs B-cell receptor signalling and can blunt antibody responses to vaccines. An inactivated hepatitis A vaccine given during treatment may therefore produce a weaker or shorter-lived protective response.
How serious is the interaction between Hepatitis A vaccine inactivated and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting ibrutinib; if given during therapy, consider checking antibody titres in at-risk patients and revaccinating after treatment ends or when immune function recovers.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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