Drug interactions
Hepatitis A vaccine inactivated + Ifosfamide
Severity: Moderate
Hepatitis A vaccine inactivated and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and immune suppression, which can blunt the antibody response to inactivated hepatitis A vaccine. The patient may remain unprotected despite vaccination.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Ifosfamide belongs to Oncology.
Why it happens
Cytotoxic suppression of lymphocytes and immune response reduces vaccine immunogenicity.
What to do
Where possible, vaccinate at least 2 weeks before starting chemotherapy. If given during or shortly before treatment, consider revaccination at least 3 months after chemotherapy ends, and check serology if protection matters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Ifosfamide?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide causes myelosuppression and immune suppression, which can blunt the antibody response to inactivated hepatitis A vaccine. The patient may remain unprotected despite vaccination.
How serious is the interaction between Hepatitis A vaccine inactivated and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate at least 2 weeks before starting chemotherapy. If given during or shortly before treatment, consider revaccination at least 3 months after chemotherapy ends, and check serology if protection matters.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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