Drug interactions
Hepatitis A vaccine inactivated + Mechlorethamine
Severity: Moderate
Hepatitis A vaccine inactivated and Mechlorethamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic mechlorethamine is cytotoxic and suppresses the immune system, which may blunt the response to inactivated vaccines. Protection may be inadequate if vaccinated during therapy.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Mechlorethamine belongs to Oncology.
Why it happens
Cytotoxic alkylating agent causing myelosuppression and lymphocyte depletion, impairing vaccine response.
What to do
Vaccinate at least 2 weeks before chemotherapy when possible; otherwise revaccinate after immune recovery or check antibody titers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Mechlorethamine?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic mechlorethamine is cytotoxic and suppresses the immune system, which may blunt the response to inactivated vaccines. Protection may be inadequate if vaccinated during therapy.
How serious is the interaction between Hepatitis A vaccine inactivated and Mechlorethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy when possible; otherwise revaccinate after immune recovery or check antibody titers.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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