Drug interactions
Hepatitis A vaccine inactivated + Melphalan
Severity: Moderate
Hepatitis A vaccine inactivated and Melphalan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melphalan causes myelosuppression and immune suppression, which can weaken the antibody response to inactivated hepatitis A vaccine. Protection may be incomplete or short-lived.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Melphalan belongs to Oncology.
Why it happens
Cytotoxic suppression of lymphocytes reduces vaccine immunogenicity.
What to do
Vaccinate at least 2 weeks before melphalan when possible. If vaccinated during therapy, revaccinate at least 3 months after treatment ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicated
- Bcg vaccine live + Melphalan Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicated
- Measles mumps and rubella vaccine live + Melphalan Contraindicated
- Measles mumps and rubella vaccine + Melphalan Contraindicated
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Melphalan?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Melphalan causes myelosuppression and immune suppression, which can weaken the antibody response to inactivated hepatitis A vaccine. Protection may be incomplete or short-lived.
How serious is the interaction between Hepatitis A vaccine inactivated and Melphalan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before melphalan when possible. If vaccinated during therapy, revaccinate at least 3 months after treatment ends.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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