Drug interactions
Hepatitis A vaccine inactivated + Rituximab
Severity: Moderate
Hepatitis A vaccine inactivated and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab depletes B cells and markedly reduces antibody responses to vaccines, so the hepatitis A vaccine may not produce protective immunity. Inactivated vaccine carries no infection risk, but protection may be inadequate.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Rituximab belongs to Musculoskeletal.
Why it happens
B-cell depletion by rituximab impairs humoral vaccine response.
What to do
Give the vaccine, where possible, at least 4 weeks before starting rituximab. If given during or after therapy, consider checking antibody titers and revaccinating after B-cell recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Rituximab?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab depletes B cells and markedly reduces antibody responses to vaccines, so the hepatitis A vaccine may not produce protective immunity. Inactivated vaccine carries no infection risk, but protection may be inadequate.
How serious is the interaction between Hepatitis A vaccine inactivated and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine, where possible, at least 4 weeks before starting rituximab. If given during or after therapy, consider checking antibody titers and revaccinating after B-cell recovery.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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