Drug interactions
Hepatitis A vaccine inactivated + Siponimod
Severity: Moderate
Hepatitis A vaccine inactivated and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod lowers circulating lymphocytes and may blunt the immune response to vaccination. An inactivated vaccine poses no infection risk, but protection may be reduced.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Siponimod belongs to Central Nervous System.
Why it happens
Siponimod sequesters lymphocytes in lymphoid tissue, which may reduce vaccine antibody responses.
What to do
Where possible, vaccinate at least one week before starting siponimod, or accept a possibly reduced response and check antibody titres if protection is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Siponimod?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod lowers circulating lymphocytes and may blunt the immune response to vaccination. An inactivated vaccine poses no infection risk, but protection may be reduced.
How serious is the interaction between Hepatitis A vaccine inactivated and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate at least one week before starting siponimod, or accept a possibly reduced response and check antibody titres if protection is needed.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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