Drug interactions
Hepatitis b vaccine + Melphalan
Severity: Moderate
Hepatitis b vaccine and Melphalan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melphalan-induced immunosuppression can reduce seroconversion after hepatitis B vaccination. Protection may be incomplete.
What this interaction means in plain words
Hepatitis b vaccine and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccine antigens.
What to do
Vaccinate at least 2 weeks before melphalan when possible. Check anti-HBs titers after vaccination and revaccinate after therapy if they are inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicated
- Bcg vaccine live + Melphalan Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicated
- Measles mumps and rubella vaccine live + Melphalan Contraindicated
- Measles mumps and rubella vaccine + Melphalan Contraindicated
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicated
Frequently asked questions
Can I take Hepatitis b vaccine with Melphalan?
MediHelp rates the interaction as moderate. Hepatitis b vaccine and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Melphalan-induced immunosuppression can reduce seroconversion after hepatitis B vaccination. Protection may be incomplete.
How serious is the interaction between Hepatitis b vaccine and Melphalan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before melphalan when possible. Check anti-HBs titers after vaccination and revaccinate after therapy if they are inadequate.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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