Drug interactions
Hepatitis b vaccine + Tocilizumab
Severity: Moderate
Hepatitis b vaccine and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hepatitis B vaccine is non-live; tocilizumab may reduce seroconversion or antibody titres. This matters in patients with ongoing exposure risk.
What this interaction means in plain words
Hepatitis b vaccine and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: IL-6 receptor blockade may impair vaccine-induced antibody response.
What to do
Vaccinate before tocilizumab where feasible. Measure anti-HBs after the series and revaccinate or boost if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hepatitis b vaccine and Tocilizumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Hepatitis b vaccine with Tocilizumab?
MediHelp rates the interaction as moderate. Hepatitis b vaccine and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hepatitis B vaccine is non-live; tocilizumab may reduce seroconversion or antibody titres. This matters in patients with ongoing exposure risk.
How serious is the interaction between Hepatitis b vaccine and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before tocilizumab where feasible. Measure anti-HBs after the series and revaccinate or boost if the response is inadequate.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
