Drug interactions
Homatropine + Tolterodine
Severity: Moderate
Homatropine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Homatropine is an antimuscarinic agent and combined with tolterodine increases anticholinergic burden. Systemic effects include dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Homatropine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Homatropine belongs to Genitourinary; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation and cognitive effects; avoid combining in older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Homatropine
- Amantadine + Homatropine Moderate
- Amitriptyline + Homatropine Moderate
- Atropine + Homatropine Moderate
- Benztropine + Homatropine Moderate
- Bethanechol + Homatropine Moderate
- Chlorpromazine + Homatropine Moderate
Frequently asked questions
Can I take Homatropine with Tolterodine?
MediHelp rates the interaction as moderate. Homatropine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Homatropine is an antimuscarinic agent and combined with tolterodine increases anticholinergic burden. Systemic effects include dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Homatropine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and cognitive effects; avoid combining in older adults where possible.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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