Drug interactions
Hops + Promethazine
Severity: Minor
Hops and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hops has mild sedative properties and may add to the drowsiness and CNS depression caused by promethazine. Impaired alertness and psychomotor performance are the main concerns.
What this interaction means in plain words
Hops and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sedative pharmacodynamic effects; hops is thought to act through GABAergic and melatonergic pathways.
What to do
Advise patients to be aware of increased drowsiness and avoid driving or hazardous tasks. Consider avoiding hops-containing sleep supplements while on promethazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Hops with Promethazine?
MediHelp rates the interaction as minor. Hops and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hops has mild sedative properties and may add to the drowsiness and CNS depression caused by promethazine. Impaired alertness and psychomotor performance are the main concerns.
How serious is the interaction between Hops and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to be aware of increased drowsiness and avoid driving or hazardous tasks. Consider avoiding hops-containing sleep supplements while on promethazine.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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