Drug interactions
Horse chestnut seed + Meclofenamic acid
Severity: Moderate
Horse chestnut seed and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut seed contains aescin and may contain coumarin-like compounds, which could theoretically impair coagulation. With an NSAID that inhibits platelets, bleeding risk may be increased, though evidence is limited.
What this interaction means in plain words
Horse chestnut seed and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical additive effects on hemostasis from NSAID platelet inhibition and possible anticoagulant activity of horse chestnut constituents.
What to do
Avoid combining where feasible. If used together, monitor for bruising and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Horse chestnut seed with Meclofenamic acid?
MediHelp rates the interaction as moderate. Horse chestnut seed and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Horse chestnut seed contains aescin and may contain coumarin-like compounds, which could theoretically impair coagulation. With an NSAID that inhibits platelets, bleeding risk may be increased, though evidence is limited.
How serious is the interaction between Horse chestnut seed and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where feasible. If used together, monitor for bruising and bleeding.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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