Drug interactions
Horse chestnut seed + Tolmetin
Severity: Moderate
Horse chestnut seed and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut seed contains aescin and, in some preparations, coumarin-like compounds that may have antithrombotic activity. With an NSAID, bleeding risk could be somewhat increased.
What this interaction means in plain words
Horse chestnut seed and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive effects on hemostasis; evidence is mainly theoretical.
What to do
Avoid concurrent use where possible. Monitor for bleeding if both are taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Horse chestnut seed and Tolmetin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Horse chestnut seed with Tolmetin?
MediHelp rates the interaction as moderate. Horse chestnut seed and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Horse chestnut seed contains aescin and, in some preparations, coumarin-like compounds that may have antithrombotic activity. With an NSAID, bleeding risk could be somewhat increased.
How serious is the interaction between Horse chestnut seed and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. Monitor for bleeding if both are taken.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
