Drug interactions
Human papillomavirus vaccine nonavalent + Ifosfamide
Severity: Moderate
Human papillomavirus vaccine nonavalent and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy immunosuppression from ifosfamide may weaken the antibody response to the HPV vaccine. Protection could be reduced if doses are given during treatment.
What this interaction means in plain words
Human papillomavirus vaccine nonavalent and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Give doses at least 2 weeks before chemotherapy where possible. Revaccinate or complete the series after immune recovery, about 3 months post-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine nonavalent with Ifosfamide?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine nonavalent and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy immunosuppression from ifosfamide may weaken the antibody response to the HPV vaccine. Protection could be reduced if doses are given during treatment.
How serious is the interaction between Human papillomavirus vaccine nonavalent and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doses at least 2 weeks before chemotherapy where possible. Revaccinate or complete the series after immune recovery, about 3 months post-therapy.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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