Drug interactions
Human papillomavirus vaccine nonavalent + Rituximab
Severity: Moderate
Human papillomavirus vaccine nonavalent and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab depletes B cells and markedly reduces antibody responses to vaccines. The non-live HPV vaccine is safe, but protection may be inadequate if given during or soon after rituximab.
What this interaction means in plain words
Human papillomavirus vaccine nonavalent and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
B-cell depletion impairs humoral response to vaccination.
What to do
Give the vaccine at least 4 weeks before rituximab where possible. Consider revaccination after B-cell recovery if given during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Frequently asked questions
Can I take Human papillomavirus vaccine nonavalent with Rituximab?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine nonavalent and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab depletes B cells and markedly reduces antibody responses to vaccines. The non-live HPV vaccine is safe, but protection may be inadequate if given during or soon after rituximab.
How serious is the interaction between Human papillomavirus vaccine nonavalent and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 4 weeks before rituximab where possible. Consider revaccination after B-cell recovery if given during therapy.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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