Drug interactions
Human papillomavirus vaccine quadrivalent + Prednisolone
Severity: Moderate
Human papillomavirus vaccine quadrivalent and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at above-physiologic doses may reduce antibody responses to this inactivated vaccine. The vaccine remains safe, but protection may be suboptimal.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid immunosuppression dampens B- and T-cell responses to vaccine antigens.
What to do
Vaccinate when corticosteroid dose is lowest, or before therapy if feasible; do not withhold needed vaccination. Consider checking response where relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Prednisolone?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine quadrivalent and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids at above-physiologic doses may reduce antibody responses to this inactivated vaccine. The vaccine remains safe, but protection may be suboptimal.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when corticosteroid dose is lowest, or before therapy if feasible; do not withhold needed vaccination. Consider checking response where relevant.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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