Drug interactions
Human papillomavirus vaccine quadrivalent + Tocilizumab
Severity: Minor
Human papillomavirus vaccine quadrivalent and Tocilizumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tocilizumab may somewhat reduce antibody responses to vaccines. HPV vaccine is non-live and can be given, so the pair does not need to be avoided.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Tocilizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
IL-6 blockade may modestly blunt the humoral response to vaccination.
What to do
Where feasible, vaccinate before starting tocilizumab. Otherwise give the vaccine as scheduled without interrupting therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Tocilizumab?
MediHelp rates the interaction as minor. Human papillomavirus vaccine quadrivalent and Tocilizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tocilizumab may somewhat reduce antibody responses to vaccines. HPV vaccine is non-live and can be given, so the pair does not need to be avoided.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Tocilizumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, vaccinate before starting tocilizumab. Otherwise give the vaccine as scheduled without interrupting therapy.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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