Drug interactions
Hyaluronidase + Phenytoin
Severity: Minor
Hyaluronidase and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin is reported to be physically incompatible with hyaluronidase when mixed, which can cause precipitation. This is a pharmaceutical incompatibility rather than a pharmacological interaction.
What this interaction means in plain words
Hyaluronidase and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyaluronidase belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Why it happens
Physicochemical incompatibility on mixing; phenytoin's alkaline solution can precipitate or inactivate proteins.
What to do
Do not mix in the same syringe or infusion line. Administer separately and flush the line between agents.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hyaluronidase and Phenytoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Hyaluronidase with Phenytoin?
MediHelp rates the interaction as minor. Hyaluronidase and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin is reported to be physically incompatible with hyaluronidase when mixed, which can cause precipitation. This is a pharmaceutical incompatibility rather than a pharmacological interaction.
How serious is the interaction between Hyaluronidase and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not mix in the same syringe or infusion line. Administer separately and flush the line between agents.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
