Drug interactions
Hydralazine + Iloprost inhaled
Severity: Moderate
Hydralazine and Iloprost inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled iloprost is a prostacyclin analogue with systemic vasodilating effects, which may add to the blood pressure lowering effect of hydralazine. Symptomatic hypotension and reflex tachycardia can occur.
What this interaction means in plain words
Hydralazine and Iloprost inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through prostacyclin receptor activation and direct arteriolar relaxation.
What to do
Monitor blood pressure and heart rate when starting iloprost in patients taking hydralazine. Lower the hydralazine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydralazine and Iloprost inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Iloprost inhaled?
MediHelp rates the interaction as moderate. Hydralazine and Iloprost inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled iloprost is a prostacyclin analogue with systemic vasodilating effects, which may add to the blood pressure lowering effect of hydralazine. Symptomatic hypotension and reflex tachycardia can occur.
How serious is the interaction between Hydralazine and Iloprost inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting iloprost in patients taking hydralazine. Lower the hydralazine dose if hypotension develops.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
