Drug interactions
Hydralazine + Ketorolac intranasal
Severity: Moderate
Hydralazine and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use and, like other NSAIDs, can reduce the blood pressure lowering effect of hydralazine. It may also impair renal function and cause fluid retention, particularly with repeated dosing.
What this interaction means in plain words
Hydralazine and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces vasodilation and promotes sodium and water retention, opposing hydralazine.
What to do
Monitor blood pressure and renal function during ketorolac courses, which are limited to short duration. Increase antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Hydralazine and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is absorbed systemically after intranasal use and, like other NSAIDs, can reduce the blood pressure lowering effect of hydralazine. It may also impair renal function and cause fluid retention, particularly with repeated dosing.
How serious is the interaction between Hydralazine and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during ketorolac courses, which are limited to short duration. Increase antihypertensive therapy if needed.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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