Drug interactions
Hydralazine + Ketorolac
Severity: Moderate
Hydralazine and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood-pressure-lowering effect of vasodilators, including hydralazine. Fluid retention and loss of blood pressure control may occur.
What this interaction means in plain words
Hydralazine and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis with sodium and water retention opposes the hydralazine effect.
What to do
Monitor blood pressure and fluid status during ketorolac use. Increase the antihypertensive dose if needed or shorten the NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Ketorolac?
MediHelp rates the interaction as moderate. Hydralazine and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood-pressure-lowering effect of vasodilators, including hydralazine. Fluid retention and loss of blood pressure control may occur.
How serious is the interaction between Hydralazine and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and fluid status during ketorolac use. Increase the antihypertensive dose if needed or shorten the NSAID course.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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