Drug interactions
Hydralazine + Meclofenamate
Severity: Moderate
Hydralazine and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce the blood pressure lowering effect of hydralazine. Sodium and fluid retention may cause a loss of blood pressure control with regular use.
What this interaction means in plain words
Hydralazine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces vasodilation and promotes sodium and water retention, opposing hydralazine.
What to do
Monitor blood pressure when the NSAID is started, stopped or changed in dose, and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Meclofenamate?
MediHelp rates the interaction as moderate. Hydralazine and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce the blood pressure lowering effect of hydralazine. Sodium and fluid retention may cause a loss of blood pressure control with regular use.
How serious is the interaction between Hydralazine and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started, stopped or changed in dose, and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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