Drug interactions
Hydralazine + Methylenedioxymethamphetamine
Severity: Moderate
Hydralazine and Methylenedioxymethamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a sympathomimetic that raises blood pressure and heart rate, which can oppose hydralazine and worsen reflex tachycardia. The combined cardiovascular strain may be significant in people with heart disease.
What this interaction means in plain words
Hydralazine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MDMA-induced release of catecholamines causes vasoconstriction and increased cardiac stimulation, opposing hydralazine.
What to do
Counsel patients to avoid recreational MDMA. Monitor blood pressure and heart rate if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as moderate. Hydralazine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a sympathomimetic that raises blood pressure and heart rate, which can oppose hydralazine and worsen reflex tachycardia. The combined cardiovascular strain may be significant in people with heart disease.
How serious is the interaction between Hydralazine and Methylenedioxymethamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid recreational MDMA. Monitor blood pressure and heart rate if exposure occurs.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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