Drug interactions
Hydralazine + Nitroglycerin rectal
Severity: Moderate
Hydralazine and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through arterial and venous vasodilation, so using them together can produce an exaggerated fall in blood pressure. Dizziness, syncope and reflex tachycardia may occur, particularly when rising from a seated position. Systemic absorption of rectal nitroglycerin is meaningful, so the effect is clinically relevant.
What this interaction means in plain words
Hydralazine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation via direct arteriolar relaxation (hydralazine) and nitric oxide-mediated venous and arterial relaxation (nitroglycerin).
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug, and counsel the patient to rise slowly. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Hydralazine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through arterial and venous vasodilation, so using them together can produce an exaggerated fall in blood pressure. Dizziness, syncope and reflex tachycardia may occur, particularly when rising from a seated position. Systemic absorption of rectal nitroglycerin is meaningful, so the effect is clinically relevant.
How serious is the interaction between Hydralazine and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug, and counsel the patient to rise slowly. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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