Drug interactions
Hydralazine + Norepinephrine
Severity: Moderate
Hydralazine and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a potent vasoconstrictor and pressor that opposes the vasodilating effect of hydralazine. The blood pressure response to either drug may be unpredictable and the hypotensive effect of hydralazine may be reduced. Hydralazine may also be present in patients on vasopressor support in critical care settings.
What this interaction means in plain words
Hydralazine and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between alpha-adrenergic vasoconstriction by norepinephrine and direct arteriolar vasodilation by hydralazine.
What to do
Titrate norepinephrine to the blood pressure target with continuous or frequent blood pressure monitoring. Reassess the need for hydralazine while the patient is receiving a vasopressor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Norepinephrine?
MediHelp rates the interaction as moderate. Hydralazine and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine is a potent vasoconstrictor and pressor that opposes the vasodilating effect of hydralazine. The blood pressure response to either drug may be unpredictable and the hypotensive effect of hydralazine may be reduced. Hydralazine may also be present in patients on vasopressor support in critical care settings.
How serious is the interaction between Hydralazine and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate norepinephrine to the blood pressure target with continuous or frequent blood pressure monitoring. Reassess the need for hydralazine while the patient is receiving a vasopressor.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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