Drug interactions
Hydralazine + Parecoxib
Severity: Moderate
Hydralazine and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib can blunt the antihypertensive effect of vasodilators and cause sodium and fluid retention. Blood pressure control may worsen, particularly with repeated dosing. The effect is generally modest and short-term perioperative use carries less risk.
What this interaction means in plain words
Hydralazine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of COX-2-mediated renal and vascular prostaglandin synthesis leads to sodium and water retention and reduced vasodilation.
What to do
Monitor blood pressure when parecoxib is used, especially beyond a few days. Use the lowest effective dose for the shortest time and adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Parecoxib?
MediHelp rates the interaction as moderate. Hydralazine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib can blunt the antihypertensive effect of vasodilators and cause sodium and fluid retention. Blood pressure control may worsen, particularly with repeated dosing. The effect is generally modest and short-term perioperative use carries less risk.
How serious is the interaction between Hydralazine and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when parecoxib is used, especially beyond a few days. Use the lowest effective dose for the shortest time and adjust antihypertensive therapy if control is lost.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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