Drug interactions
Hydralazine + Penbutolol
Severity: Minor
Hydralazine and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a vasodilator with a beta-blocker lowers blood pressure further than either alone. This combination is often used deliberately, because the beta-blocker limits the reflex tachycardia caused by hydralazine. Excessive hypotension or bradycardia is still possible, particularly at initiation.
What this interaction means in plain words
Hydralazine and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering through arteriolar vasodilation plus beta-adrenergic blockade, with beta-blockade attenuating hydralazine-induced reflex tachycardia.
What to do
Monitor blood pressure and heart rate when starting or changing doses. Adjust doses to the desired blood pressure target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Penbutolol?
MediHelp rates the interaction as minor. Hydralazine and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a vasodilator with a beta-blocker lowers blood pressure further than either alone. This combination is often used deliberately, because the beta-blocker limits the reflex tachycardia caused by hydralazine. Excessive hypotension or bradycardia is still possible, particularly at initiation.
How serious is the interaction between Hydralazine and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses. Adjust doses to the desired blood pressure target.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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