Drug interactions
Hydralazine + Phendimetrazine
Severity: Moderate
Hydralazine and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate. It may reduce the effectiveness of hydralazine and complicate blood pressure control. Tachycardia may be additive with hydralazine-induced reflex tachycardia.
What this interaction means in plain words
Hydralazine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism, as sympathomimetic release of norepinephrine opposes the vasodilation produced by hydralazine.
What to do
Monitor blood pressure and heart rate regularly during co-therapy. Reconsider the use of the anorectic if hypertension is difficult to control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Phendimetrazine?
MediHelp rates the interaction as moderate. Hydralazine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic that can raise blood pressure and heart rate. It may reduce the effectiveness of hydralazine and complicate blood pressure control. Tachycardia may be additive with hydralazine-induced reflex tachycardia.
How serious is the interaction between Hydralazine and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate regularly during co-therapy. Reconsider the use of the anorectic if hypertension is difficult to control.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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