Drug interactions
Hydralazine + Pindolol
Severity: Minor
Hydralazine and Pindolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydralazine and the beta-blocker pindolol have additive blood pressure lowering effects. The combination is established in hypertension management, as beta-blockade reduces reflex tachycardia from hydralazine. Hypotension or bradycardia can occur, particularly when starting treatment or increasing doses.
What this interaction means in plain words
Hydralazine and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure reduction through direct arteriolar vasodilation and beta-adrenergic blockade, which blunts reflex tachycardia.
What to do
Monitor blood pressure and heart rate when initiating or changing either drug. Titrate doses to the blood pressure goal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Pindolol?
MediHelp rates the interaction as minor. Hydralazine and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydralazine and the beta-blocker pindolol have additive blood pressure lowering effects. The combination is established in hypertension management, as beta-blockade reduces reflex tachycardia from hydralazine. Hypotension or bradycardia can occur, particularly when starting treatment or increasing doses.
How serious is the interaction between Hydralazine and Pindolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when initiating or changing either drug. Titrate doses to the blood pressure goal.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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