Drug interactions
Hydralazine + Pyridoxine
Severity: Moderate
Hydralazine and Pyridoxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydralazine can bind pyridoxal and its phosphate to form hydrazones, which promotes pyridoxine deficiency. Prolonged therapy may lead to peripheral neuropathy, especially in slow acetylators or with high doses.
What this interaction means in plain words
Hydralazine and Pyridoxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Hydralazine's hydrazine group reacts with pyridoxal and pyridoxal phosphate, inactivating vitamin B6 and increasing its excretion.
What to do
Watch for paresthesias or neuropathy during long-term or high-dose hydralazine. Give pyridoxine supplementation if symptoms or risk factors for deficiency are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Pyridoxine?
MediHelp rates the interaction as moderate. Hydralazine and Pyridoxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydralazine can bind pyridoxal and its phosphate to form hydrazones, which promotes pyridoxine deficiency. Prolonged therapy may lead to peripheral neuropathy, especially in slow acetylators or with high doses.
How serious is the interaction between Hydralazine and Pyridoxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for paresthesias or neuropathy during long-term or high-dose hydralazine. Give pyridoxine supplementation if symptoms or risk factors for deficiency are present.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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