Drug interactions
Hydralazine + Salicylates
Severity: Minor
Hydralazine and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can inhibit prostaglandins and may cause sodium and fluid retention, potentially weakening the blood pressure lowering effect of hydralazine. The effect is usually small, particularly at low analgesic doses. Higher or prolonged dosing makes it more likely.
What this interaction means in plain words
Hydralazine and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of prostaglandin synthesis reduces vasodilation and promotes renal sodium and water retention, opposing the antihypertensive effect.
What to do
Monitor blood pressure if salicylates are used regularly at higher doses. Adjust the antihypertensive regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Salicylates?
MediHelp rates the interaction as minor. Hydralazine and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates can inhibit prostaglandins and may cause sodium and fluid retention, potentially weakening the blood pressure lowering effect of hydralazine. The effect is usually small, particularly at low analgesic doses. Higher or prolonged dosing makes it more likely.
How serious is the interaction between Hydralazine and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if salicylates are used regularly at higher doses. Adjust the antihypertensive regimen if control worsens.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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