Drug interactions
Hydralazine + Salsalate
Severity: Moderate
Hydralazine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate NSAID, may blunt the antihypertensive effect of hydralazine by promoting fluid retention and reducing prostaglandin-mediated vasodilation. The magnitude of the effect varies between patients. Regular use increases the likelihood of reduced blood pressure control.
What this interaction means in plain words
Hydralazine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and water retention and attenuates vasodilation.
What to do
Monitor blood pressure when salsalate is started, stopped or changed in dose. Use the lowest effective dose and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Salsalate?
MediHelp rates the interaction as moderate. Hydralazine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate NSAID, may blunt the antihypertensive effect of hydralazine by promoting fluid retention and reducing prostaglandin-mediated vasodilation. The magnitude of the effect varies between patients. Regular use increases the likelihood of reduced blood pressure control.
How serious is the interaction between Hydralazine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when salsalate is started, stopped or changed in dose. Use the lowest effective dose and adjust antihypertensive therapy if needed.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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