Drug interactions
Hydralazine + Serdexmethylphenidate / dexmethylphenidate
Severity: Moderate
Hydralazine and Serdexmethylphenidate / dexmethylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate-type stimulants can raise blood pressure and heart rate. This may reduce the effect of hydralazine and lead to poorer blood pressure control. Additive tachycardia is also possible.
What this interaction means in plain words
Hydralazine and Serdexmethylphenidate / dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic stimulation through increased catecholamine availability opposes the vasodilating effect of hydralazine.
What to do
Monitor blood pressure and heart rate at baseline and during treatment. Adjust the antihypertensive regimen or the stimulant dose if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as moderate. Hydralazine and Serdexmethylphenidate / dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate-type stimulants can raise blood pressure and heart rate. This may reduce the effect of hydralazine and lead to poorer blood pressure control. Additive tachycardia is also possible.
How serious is the interaction between Hydralazine and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at baseline and during treatment. Adjust the antihypertensive regimen or the stimulant dose if hypertension develops.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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