Drug interactions
Hydralazine + Valoctocogene roxaparvovec
Severity: Moderate
Hydralazine and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes transaminase elevations. Hydralazine can rarely cause liver injury, so concurrent use may complicate the interpretation of liver enzyme changes. The risk is theoretical and mostly additive.
What this interaction means in plain words
Hydralazine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Potential additive hepatotoxicity; no specific pharmacokinetic mechanism has been established.
What to do
Monitor liver enzymes regularly as recommended after gene therapy infusion. Consider alternatives to potentially hepatotoxic drugs if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Hydralazine with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Hydralazine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes transaminase elevations. Hydralazine can rarely cause liver injury, so concurrent use may complicate the interpretation of liver enzyme changes. The risk is theoretical and mostly additive.
How serious is the interaction between Hydralazine and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes regularly as recommended after gene therapy infusion. Consider alternatives to potentially hepatotoxic drugs if transaminases rise.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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