Drug interactions
Hydralazine + Vitamin B6
Severity: Minor
Hydralazine and Vitamin B6: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydralazine can bind pyridoxal and form hydrazones, which may lower functional vitamin B6 and rarely contributes to peripheral neuropathy. This is mainly relevant with prolonged or high-dose hydralazine therapy, especially in slow acetylators.
What this interaction means in plain words
Hydralazine and Vitamin B6 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Vitamin B6 belongs to Gastrointestinal Tract.
Why it happens
Hydralazine's hydrazine group reacts with pyridoxal and pyridoxal phosphate, forming inactive complexes and increasing pyridoxine requirements.
What to do
Monitor for paresthesias or neuropathy during long-term hydralazine use and give pyridoxine supplementation if symptoms or risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin B6
- Ethotoin + Vitamin B6 Moderate
- Fosphenytoin + Vitamin B6 Moderate
- Isoniazid + Vitamin B6 Moderate
- Levodopa + Vitamin B6 Moderate
- Penicillamine + Vitamin B6 Moderate
- Phenobarbital + Vitamin B6 Moderate
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Vitamin B6?
MediHelp rates the interaction as minor. Hydralazine and Vitamin B6 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydralazine can bind pyridoxal and form hydrazones, which may lower functional vitamin B6 and rarely contributes to peripheral neuropathy. This is mainly relevant with prolonged or high-dose hydralazine therapy, especially in slow acetylators.
How serious is the interaction between Hydralazine and Vitamin B6?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paresthesias or neuropathy during long-term hydralazine use and give pyridoxine supplementation if symptoms or risk factors are present.
What other medicines interact with Vitamin B6?
MediHelp also lists interactions of Vitamin B6 with, for example, Ethotoin, Fosphenytoin, Isoniazid. The full list is on the Vitamin B6 page.
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